6533b828fe1ef96bd128904a
RESEARCH PRODUCT
Suggestive evidence for association of D2S2188 marker (2q31.1) with autism in 143 Sicilian (Italian) TRIO families
RomanoMaurizio EliaFabio CanzianiRosalba D'annaMario G. MirisolaGregorio SeiditaG GambinoSalvatore RomanoFilippo CaliDe Leo GP. SchinoccaG.f. Ayalasubject
Genetic MarkersLinkage disequilibriumDisequilibriumEthnic groupautism ds2188 pcrDiseaseBiologyPopulation stratificationSettore BIO/13 - Biologia ApplicataPolymorphism (computer science)GeneticsmedicineHumansFamilyAutistic DisorderSicilyBiological PsychiatryGenetics (clinical)GeneticsPolymorphism GeneticChromosome Mappingmedicine.diseaselanguage.human_languagePsychiatry and Mental healthChromosomes Human Pair 2languageAutismmedicine.symptomSiciliandescription
We have screened 143 Sicilian (Italian) families with one autistic child to verify, by a linkage disequilibrium approach, the involvement of the 2q31.1 region in the cause of the disease in these families. Our study design includes the use of intrafamilial association to prevent a population stratification bias and ethnic homogeneity of the sample. The results of our analysis provided suggestive evidence of the occurrence of transmission disequilibrium between autism and the D2S2188 polymorphism in Sicilian TRIO families, a finding which provides further and independent support to the hypothesis of the existence of a susceptibility gene (or genes) for autism on chromosome 2q.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-01 | Psychiatric Genetics |