6533b828fe1ef96bd12890ac
RESEARCH PRODUCT
Mitochondrial damage in aging and apoptosis.
Ana LloretConsuelo BorrasJuan SastreFederico V. PallardóJose ViñaDavid García-salasubject
Malemedicine.medical_specialtyMitochondrial DNAAgingApoptosisMitochondrionGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundHistory and Philosophy of ScienceInternal medicinemedicineAnimalsSex CharacteristicsbiologyLife spanGinkgo bilobaGeneral NeuroscienceGlutathionebiology.organism_classificationMitochondriaRatsOxidative StressEndocrinologyBiochemistrychemistryApoptosisCellular AgingOvariectomized ratFemaleReactive Oxygen Speciesdescription
: Mitochondria are essential to cellular aging, and free radical production by mitochondria is increased with aging. The rate of oxidant production by mitochondria correlates inversely with maximal life span of species. In many species, females live longer than males. We report that mitochondrial oxidant production by females is significantly lower than that of males. However, mitochondria from ovariectomized females have a similar oxidant production as those of males. Thus, gender difference in life span can be explained, at least in part, by different oxidant generation by mitochondria. Administration of antioxidants, such as vitamins C and E, or a Ginkgo biloba extract, protects against age-associated oxidative damage to mitochondrial DNA, oxidation of glutathione, and other signs of oxidative damage to mitochondria.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-04-27 | Annals of the New York Academy of Sciences |