Phase 1 study of biweekly (Q2W) anti-EGFR monoclonal antibody (mAb) mixture Sym004 in patients (pts) with metastatic colorectal cancer (mCRC) resistant to previous anti-EGFR treatment.

6533b829fe1ef96bd12896dd

RESEARCH PRODUCT

Phase 1 study of biweekly (Q2W) anti-EGFR monoclonal antibody (mAb) mixture Sym004 in patients (pts) with metastatic colorectal cancer (mCRC) resistant to previous anti-EGFR treatment.

Susana Rosello Keranen Guillem Argiles Rodrigo Dienstmann Andrés Cervantes Niels Jorgen Ostergaard Skartved Ulla H. Hansen Stephan Braun Marta Benavent Viñuales Rocio Garcia Carbonero Ivan D. Horak

subject

Cancer Research Cetuximab Colorectal cancer medicine.drug_class business.industry medicine.disease Monoclonal antibody medicine.disease_cause digestive system diseases Oncology medicine Cancer research Panitumumab In patient KRAS Anti-EGFR Monoclonal Antibody business neoplasms medicine.drug

description

3551 Background: Preclinical models suggest that WT KRAS mCRC may retain EGFR dependency despite resistance developed to anti-EGFR mAb treatment (eg, cetuximab or panitumumab). Sym004 is the first-...

year	journal	country	edition	language
2014-05-20	Journal of Clinical Oncology

https://doi.org/10.1200/jco.2014.32.15_suppl.3551

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