6533b829fe1ef96bd1289991

RESEARCH PRODUCT

An easy access to fused chromanones via rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins

M. ShimiM. ShimiNayana JosephAjesh VijayanAjesh VijayanKokkuvayil Vasu RadhakrishnanKokkuvayil Vasu RadhakrishnanE. JijySunil VarughesePetri M. PihkoThekke V. BaijuThekke V. BaijuPraveen Prakash

subject

diazabicyclic olefinsBicyclic moleculechromanone010405 organic chemistryOrganic Chemistrychemistry.chemical_elementrhodium catalyzedsalicylaldehyde010402 general chemistry01 natural sciencesBiochemistry0104 chemical sciencesRhodiumCatalysischemistry.chemical_compoundchemistrySalicylaldehydeDrug DiscoveryOrganic chemistryOxidative coupling of methaneUrea derivativesta116urea derived bicyclic olefins

description

Abstract Herein we describe a detailed study on the rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins such as diazabicyclic olefins and urea-derived bicyclic olefins. The developed method provides an ideal route to fused chromanone systems in a single synthetic step. Moreover, the scope of this methodology was extended to different oxa/aza-bridged bicyclic urea derivatives.

yearjournalcountryeditionlanguage
2016-07-01Tetrahedron
https://doi.org/10.1016/j.tet.2016.05.031