Search results for "chromanone"

showing 4 items of 4 documents

Crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one

2019

The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3, I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one, C22H16O3, II, are reported. These compounds are of interest with respect to biological activity. Both structures display intermolecular C—H...O and O—H...O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by π–π interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C...H interaction in the Hirshfeld surface.

crystal structurelipophilicity index010405 organic chemistryChemistryHydrogen bondGeneral ChemistryCrystal structure010402 general chemistryCondensed Matter Physicschromanone derivative01 natural sciences0104 chemical scienceslcsh:ChemistryCrystallographylcsh:QD1-999hirshfeld surface analysisLipophilicityHirshfeld surface analysisGeneral Materials Scienceflavanone derivativeActa Crystallographica Section E Crystallographic Communications
researchProduct

An easy access to fused chromanones via rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins

2016

Abstract Herein we describe a detailed study on the rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins such as diazabicyclic olefins and urea-derived bicyclic olefins. The developed method provides an ideal route to fused chromanone systems in a single synthetic step. Moreover, the scope of this methodology was extended to different oxa/aza-bridged bicyclic urea derivatives.

diazabicyclic olefinsBicyclic moleculechromanone010405 organic chemistryOrganic Chemistrychemistry.chemical_elementrhodium catalyzedsalicylaldehyde010402 general chemistry01 natural sciencesBiochemistry0104 chemical sciencesRhodiumCatalysischemistry.chemical_compoundchemistrySalicylaldehydeDrug DiscoveryOrganic chemistryOxidative coupling of methaneUrea derivativesta116urea derived bicyclic olefinsTetrahedron
researchProduct

An easy access to fused chromanones via rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins

2016

Herein we describe a detailed study on the rhodium catalyzed oxidative coupling of salicylaldehydes with heterobicyclic olefins such as diazabicyclic olefins and urea-derived bicyclic olefins. The developed method provides an ideal route to fused chromanone systems in a single synthetic step. Moreover, the scope of this methodology was extended to different oxa/aza-bridged bicyclic urea derivatives. peerReviewed

diazabicyclic olefinschromanonerhodium catalyzedsalicylaldehydeurea derived bicyclic olefins
researchProduct

Asymmetric Organocatalytic Synthesis of 4-Aminoisochromanones via a Direct One-Pot Intramolecular Mannich Reaction

2016

Synthesis 48(24), 4451 - 4458(2016). doi:10.1055/s-0035-1562522

one-pot reaction010405 organic chemistryChemistryOrganic Chemistryasymmetric synthesisEnantioselective synthesis010402 general chemistry54001 natural sciencesMedicinal chemistryCatalysis0104 chemical sciencesCatalysisIntramolecular forceOne pot reactionOrganocatalysisddc:540isochromanonesMannich reactionOrganic chemistryAmine gas treatingStereoselectivityorganocatalysisMannich reactionorganocatalysis; one-pot reaction; asymmetric synthesis; isochromanones; Mannich reaction
researchProduct