6533b829fe1ef96bd128a2f2

RESEARCH PRODUCT

Comparative study of the effect of gentamicin on the vestibulo-ocular and visual vestibulo-ocular reflexes in the cat.

Vicente HonrubiaJ. Marco-algarra

subject

Vestibular systemmedicine.medical_specialtyCATSgenetic structuresbusiness.industryAminoglycosideGeneral MedicineReflex Vestibulo-OcularAudiologyVestibular Function TestsPeak responseOtorhinolaryngologyReflexCatsMedicineAnimalsGentamicinsense organsProspective StudiesVestibulo–ocular reflexGentamicinsbusinessAfter treatmentPhotic Stimulationmedicine.drug

description

The ototoxic effect of an aminoglycoside, gentamicin, on the vestibular system was investigated in cats given daily doses of 40 mg/kg i.m. for 14 days. Periodically, measurements were made of the vestibulo-ocular reflex (VOR) and visual vestibulo-ocular reflex (ViVOR) responses induced by rotatory stimuli at various frequencies from 0.0125 Hz to 0.8 Hz. After the cessation of drug administration, a progressively declining response to VOR stimuli continued, manifested by gain (ratio of peak response to peak stimulus amplitude) and phase relationships. The ViVOR was affected only in the gain measurements. The changes in the response amplitude (gain) were greater for the VOR than for the ViVOR responses and also for the lower (0.0125 Hz) than for the higher frequencies (0.8 Hz). There was some indication that the responses improved about one month after treatment was terminated. All of these specific response changes in cats are comparable to the known effects of aminoglycides in humans, and the same theoretical interpretation of the data in the context of a model of vestibular function can be applied in both cases.

yearjournalcountryeditionlanguage
1991-01-01Acta oto-laryngologica
10.3109/00016489109137369https://pubmed.ncbi.nlm.nih.gov/2068897