0000000000447643
AUTHOR
J. Marco-algarra
Cis-diaminedichloro platinum ototoxicity. An experimental study.
Four groups of guinea pigs received different doses of cis-platinum. SEM and TEM showed a direct relation between the dose and the damage. The first row of OHC is the first one to be damaged. The IHC are more resistant than the OHC. The pattern of destruction is similar to the one produced by the aminoglucoside antibiotics.
Comparative study of the effect of gentamicin on the vestibulo-ocular and visual vestibulo-ocular reflexes in the cat.
The ototoxic effect of an aminoglycoside, gentamicin, on the vestibular system was investigated in cats given daily doses of 40 mg/kg i.m. for 14 days. Periodically, measurements were made of the vestibulo-ocular reflex (VOR) and visual vestibulo-ocular reflex (ViVOR) responses induced by rotatory stimuli at various frequencies from 0.0125 Hz to 0.8 Hz. After the cessation of drug administration, a progressively declining response to VOR stimuli continued, manifested by gain (ratio of peak response to peak stimulus amplitude) and phase relationships. The ViVOR was affected only in the gain measurements. The changes in the response amplitude (gain) were greater for the VOR than for the ViVOR…
The prognostic value of mucociliary clearance in predicting success in tympanoplasty
AbstractMucociliary and equipressive eustachian tube functions have been studied, using saccharin solution (five per cent sodium saccharinate) and tubal manometry respectively, in 58 ears with chronic disease undergoing tympanoplasty. The position of the perforation site determines the results as the poorest results are obtained from the posterior ones, positive cases (47 per cent) and mean transport time (37.7 minutes), compared to the greater percentage of positive cases (86 per cent) and mean transport time (22.2 minutes) for anterior perforations.When both parameters are analysed together there is a direct relationship between normal equipressive function and normal mucociliary transpor…