6533b81ffe1ef96bd1277c3e

RESEARCH PRODUCT

Cis-diaminedichloro platinum ototoxicity. An experimental study.

J. Marco-algarraJorge BasterraJaime Marco

subject

medicine.medical_specialtymedicine.drug_classAntibioticsGuinea Pigschemistry.chemical_elementCis-platinumPharmacologyInjections IntramuscularOtotoxicityHair Cells AuditoryMedicineAnimalsHearing LossOrgan of Cortibusiness.industryGeneral Medicinemedicine.diseaseSurgeryMicroscopy Electronmedicine.anatomical_structureOtorhinolaryngologychemistryOrgan of CortiToxicityMicroscopy Electron ScanningKidney Diseasessense organsCisplatinbusinessPlatinumInjections Intraperitoneal

description

Four groups of guinea pigs received different doses of cis-platinum. SEM and TEM showed a direct relation between the dose and the damage. The first row of OHC is the first one to be damaged. The IHC are more resistant than the OHC. The pattern of destruction is similar to the one produced by the aminoglucoside antibiotics.

yearjournalcountryeditionlanguage
1985-03-01Acta oto-laryngologica
10.3109/00016488509108921https://pubmed.ncbi.nlm.nih.gov/4040310