6533b829fe1ef96bd128a43a
RESEARCH PRODUCT
Oral vinorelbine and capecitabine as first-line therapy in metastatic breast cancer: a retrospective analysis
Pietro SpadaroCalogero CipollaConcetta ArcanàMaria Rosaria ValerioDario PiazzaPaolo VigneriVittorio GebbiaNicolò Borsellinosubject
Oncologymedicine.medical_specialtySettore MED/06 - Oncologia Medicamedicine.medical_treatmentVinorelbineCapecitabineStable DiseaseInternal medicineCarcinomamedicinebreast carcinomaoral chemotherapymetastasesChemotherapybusiness.industrycapecitabinemedicine.diseaseMetastatic breast cancervinorelbineSettore MED/18 - Chirurgia GeneraleToxicitybusinessBreast carcinomaBiotechnologymedicine.drugResearch Articledescription
A retrospective analysis of 70 patients with triple-negative or hormone-resistant advanced breast carcinoma who had not previously received chemotherapy was carried out. Patients received oral vinorelbine 60 mg/m2 on day 1 and 8, plus capecitabine 1000 mg/m2 bid for 14 consecutive days every 3 weeks. Overall response rate was 53% with a 9% complete response rate. Stable disease was recorded in 27% of the cases. Median progression-free survival was 7.9 months and median overall survival was 29.2 months. Toxicity was generally mild and easily manageable. These data demonstrate that this combination is feasible, safe and active as first-line treatment of triple-negative fully hormone-resistant advanced breast carcinoma patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-11-01 |