6533b829fe1ef96bd128a56b
RESEARCH PRODUCT
Genetic polymorphism of human complement factor I (C3b inactivator) in the Chinese Han population.
Peter M. SchneiderChristian RittnerBeate Stradmann-bellinghausenLin Zhangsubject
GeneticsChinaPolymorphism GeneticGenotypeIsoelectric focusingImmunologyComplement factor IBiologyMolecular biologyEdta plasmaChinese han populationAsian PeopleComplement Factor IC3b inactivatorGeneticsHumansPolyacrylamide gel electrophoresisGenetics (clinical)Allelesdescription
The human complement factor I (IF) polymorphism has been analysed by polyacrylamide gel isoelectric focusing electrophoresis of neuraminidase-treated EDTA plasma samples followed by immunoblotting and enzymatic detection. In a population study among 121 random individuals from Chengdu, PR China, three different common phenotypes were observed. The results show that IF is polymorphic in the Chinese population. The allele frequencies were as follows: FI*A = 0.153, FI*B = 0.847. The distribution of observed phenotypes was in accordance with the Hardy-Weinberg equilibrium. In comparison to other Asian population studies, the frequency of the IF*A allele was the highest in the Chinese population studied here.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-03-24 | Experimental and clinical immunogenetics |