Funktionelle Bedeutung der Freisetzung von Dihydroxyephedrin und Dihydroxypseudoephedrin als ?falschen? sympathischen �bertr�gerstoffen am Herzen

6533b829fe1ef96bd128ab82

RESEARCH PRODUCT

Funktionelle Bedeutung der Freisetzung von Dihydroxyephedrin und Dihydroxypseudoephedrin als ?falschen? sympathischen �bertr�gerstoffen am Herzen

subject

Pharmacology medicine.medical_specialty Endocrinology Stereochemistry Chemistry Rabbit heart Internal medicine Pharmacology toxicology medicine Potency Functional significance General Medicine

description

The experiments were carried out in order to investigate the functional significance of substitution of noradrenaline by amines known to exert actions weaker than those of the natural transmitter. On the isolated rabbit heart the potency relative to noradrenaline of (±)-dihydroxyephedrine to increase the rate was 1/4 and the potency to augment the contractile amplitude was 1/6. The corresponding values for (±)-dihydroxypseudoephedrine were 1/67 and 1/140, respectively.

year	journal	country	edition	language
1967-01-01	Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie

https://doi.org/10.1007/bf00585355

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