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RESEARCH PRODUCT

New Acylated Triterpene Saponins from Silene fortunei that Modulate Lymphocyte Proliferation

Véronique LaurensTomofumi MiyamotoMarie Aleth Lacaille-duboisGhezala Gaidi

subject

SaponinPhytoecdysteroidPharmaceutical ScienceApoptosisLymphocyte proliferationPharmacognosyLymphocyte ActivationPlant RootsJurkat cellsAnalytical ChemistryJurkat CellsTriterpeneDrug DiscoveryHumansSileneNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationSilenePlants MedicinalMolecular StructurebiologyHydrolysisOrganic ChemistryGlycosideAcetylationStereoisomerismSaponinsbiology.organism_classificationTriterpenesComplementary and alternative medicinechemistryBiochemistryMolecular Medicine

description

Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.

yearjournalcountryeditionlanguage
2002-11-26Journal of Natural Products
https://doi.org/10.1021/np020105a