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RESEARCH PRODUCT
Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy
Maria F. Garcia-parajoJosé RivasM. Carmen BlancoCarmen CarneiroGiampaolo BaroneTomás García-caballeroBlanca DominguezKyra J. E. BorgmanFernando DomínguezMelike LakadamyaliNatalia BustoBegoña GarcíaErea BorrajoJosé M. LealJosé L. BlancoM. Arturo López-quintelaVanesa PortoJose I. NeissaDavid BucetaShahana Huseyinovasubject
0301 basic medicineMaterials sciencemedicine.medical_treatment010402 general chemistry01 natural sciences03 medical and health scienceschemistry.chemical_compoundsilver clusterTherapeutic indexmedicineCarcinomaCytotoxic T cellGeneral Materials ScienceMechanics of MaterialCisplatinChemotherapyDNA-binding drugMechanical EngineeringDNA replicationmedicine.disease0104 chemical sciences3. Good healthChromatin030104 developmental biologychemistryMechanics of Materialschromatin accessibilityCancer researchatomic quantum clustercancer therapyMaterials Science (all)DNAmedicine.drugdescription
Nanomaterials with very low atomicity deserve consideration as potential pharmacological agents owing to their very small size and to their properties that can be precisely tuned with minor modifications to their size. Here, it is shown that silver clusters of three atoms (Ag3 -AQCs)-developed by an ad hoc method-augment chromatin accessibility. This effect only occurs during DNA replication. Coadministration of Ag3 -AQCs increases the cytotoxic effect of DNA-acting drugs on human lung carcinoma cells. In mice with orthotopic lung tumors, the coadministration of Ag3 -AQCs increases the amount of cisplatin (CDDP) bound to the tumor DNA by fivefold without modifying CDDP levels in normal tissues. As a result, CDDP coadministered with Ag3 -AQCs more strongly reduces the tumor burden. Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is now provided.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-27 |