6533b829fe1ef96bd128afeb

RESEARCH PRODUCT

Polarimetry as a useful tool for the determination of binding constants between cyclodextrins and organic guest molecules

Francesca D'annaRenato NotoPaolo Lo MeoSerena RielaMichelangelo Gruttadauria

subject

chemistry.chemical_classificationCyclodextrinchemistryComputational chemistryOrganic ChemistryDrug DiscoveryPolarimetryAnalytical chemistryMoleculecyclodextrin polarimetry host-guest interactionsSettore CHIM/06 - Chimica OrganicaBiochemistry

description

Binding constants for cyclodextrin inclusion complexes can be easily estimated by means of simple polarimetric measurements. Determinations are as reliable and accurate as those obtained by means of other more sophisticated techniques, and take advantage by the limited waste of material required. Our results are briefly compared with literature values obtained by means of different techniques.

yearjournalcountryeditionlanguage
2006-12-01
10.1016/j.tetlet.2006.10.078http://hdl.handle.net/10447/5521