6533b82afe1ef96bd128b654
RESEARCH PRODUCT
Brain metastases following interleukin-2 plus interferon-alpha-2a therapy
Ulrich KeilholzR. Engenhart-cabillicA.-m. GeuekeAlexander SchmittelCarmen ScheibenbogenEckhard ThielT Proebstlesubject
Cancer Researchmedicine.medical_specialtybusiness.industryMelanomamedicine.medical_treatmentCentral nervous systemAlpha interferonmedicine.diseaseGastroenterologyMetastasisSurgeryCentral nervous system diseaseRadiation therapymedicine.anatomical_structureOncologyInternal medicinemedicineComplicationbusinessInterferon alfamedicine.drugdescription
Abstract This study analyses the frequency and therapy of brain metastases in 94 stage IV melanoma patients after treatment with high-dose interleukin-2 (IL-2) and interferon-α (IFN-α) within three subsequent trials between 1990 and 1995. Central nervous system (CNS) metastases occurred in 28 patients (30%) during the potential follow-up period of 6 years. Time to occurence of brain metastases varied between 1 and 53 months, with a median of 10 months. Of 28 patients, 19 had
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-03-01 | European Journal of Cancer |