6533b82afe1ef96bd128b662

RESEARCH PRODUCT

Calorimetric investigation of the interaction between a macromolecular prodrug of diflunisal and human platelets

V. ArcoleoGennara CavallaroG. La MannaV. Turco Liveri

subject

Macromolecular prodrugsStereochemistryChemistryThermal effectBiophysicsmedicineDiflunisalPlateletProdrugIn vitroMacromoleculemedicine.drugConjugate

description

The thermal effect due to the interaction between human platelets and α,β poly(N-hydroxy-ethyl)-DL-aspartamide (PHEA) or the PHEA-Diflunisal conjugate was measured by the calorimetric technique at 25°C. The experimental data confirm that PHEA is a biocompatible macromolecule and that its conjugate influences the physiological activity of human platelets.

https://doi.org/10.1007/bf02549234