Genotoxicity of the fungicide dichlofluanid in seven assays

6533b82afe1ef96bd128b8bf

RESEARCH PRODUCT

Genotoxicity of the fungicide dichlofluanid in seven assays

J. Heil G. Reifferscheid D. Hellmich M. Hergenröder R. K. Zahn R. B. Setlow

subject

DNA Replication Salmonella typhimurium DNA Alteration Epidemiology Health Toxicology and Mutagenesis Dichlofluanid medicine.disease_cause Cell Line Mice chemistry.chemical_compound medicine Animals Humans Bioassay Genetics (clinical)Captan Carcinogen Aniline Compounds Mutagenicity Tests Fishes DNA Pesticide Fungicides Industrial Fungicide Biochemistry chemistry Genotoxicity DNA Damage HeLa Cells Mutagens

description

Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu-test, alkaline filter elution, FADU-test, 32P-postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.

year	journal	country	edition	language
1991-01-01	Environmental and Molecular Mutagenesis

https://doi.org/10.1002/em.2850170104

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