6533b82afe1ef96bd128c135
RESEARCH PRODUCT
Colletotrin: a sesquiterpene lactone from the endophytic fungus Colletotrichum gloeosporioides associated with Trichilia monadelpha
Liu ZhenSergi Herve AkoneSergi Herve AkoneArmelle Tsamo TontsaArmelle Tsamo TontsaPamela Nangmo KemdaPamela Nangmo KemdaAugustin Ephrem NkengfackWerner E.g. MüllerPeter Prokschsubject
0301 basic medicinechemistry.chemical_classificationMeliaceaebiologyTraditional medicineChemistryElectrospray ionization030106 microbiologyGeneral Chemistrybiology.organism_classificationTrichilia monadelphaSesquiterpene lactoneEndophytePlant use of endophytic fungi in defense03 medical and health sciences030104 developmental biologyHeteronuclear moleculeColletotrichum gloeosporioidesdescription
Abstract A new sesquiterpene lactone, namely colletotrin (1), together with two known fungal metabolites (2, 3), was obtained from a rice culture of Colletotrichum gloeosporioides, an endophytic fungus isolated from the stem bark of Cameroonian medicinal plant Trichilia monadelpha (Meliaceae). The structure of the new compound was established on the basis of extensive NMR analysis (1H, 13C, heteronuclear single-quantum coherence and heteronuclear multiple-bond correlation) completed by high-resolution electrospray ionization mass spectroscopy results and by comparison of these data with those of related compounds described in the literature. Their cytotoxic and antibacterial activities against the mouse lymphoma L5178Y cell line and Mycobacterium tuberculosis, respectively, were also evaluated. This study is the first report on the isolation of fungal metabolites from endophytic fungi associated with T. monadelpha (Meliaceae).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-09-23 | Zeitschrift für Naturforschung B |