6533b82afe1ef96bd128c152

RESEARCH PRODUCT

Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis

J-d De SouzaR-d ColettaM-f-l De FigueiredoF-t BarbosaHercílio Martelli-júniorD-r-b MartelliL-g-v CoelhoE-f CardosoR-a Machado

subject

MaleCross-sectional studyCleft LipDentistry03 medical and health sciences0302 clinical medicineStomach NeoplasmsPrevalencemedicineHumansIn patientFamily historyFirst-degree relativesGeneral DentistryAnodontiaOral Medicine and PathologyOral cleftbusiness.industryResearchCase-control studyBrainCancer030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseCleft PalateCross-Sectional StudiesOtorhinolaryngologyCase-Control Studies030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASFemaleSurgeryTooth agenesisbusiness

description

Background To determine the frequency of nonsyndromic cleft lip and/or palate (NSCL/P) in first-degree relatives and to analyze the prevalence of tooth agenesis in patients with gastric cancer. Material and Methods This cross-sectional, observational, case-control study included 798 patients attended at hospital Santa Casa in Montes Claros, Minas Gerais and Alfa Institute of Gastroenterology of the Federal University of the Minas Gerais. Information on basic demographic data and tooth agenesis of both groups and their family history of NSCL/P in first-degree relatives were evaluated. The collected information was stored in a database and analyzed using statistical program SPSS® version 21.0 and the values with p<0.05 were considered statistically significant. Results Of the 798 patients, 113 (14.16%) consisted of the case group and 685 of the control group (85.84%). Non-Caucasian males were the most affected, although no differences among the groups were detected. Of all participants (n=798), 66 (8.27%) presented tooth agenesis and 25 (3.13%) presented oral cleft in first degree relative. Conclusions Our results no found increase in the frequency of tooth agenesis in patients with gastric cancer and in the frequency of NSCL/P in the first-degree relatives of patients with gastric cancer. Key words:Nonsyndromic cleft lip and/or palate, tooth agenesis, gastric cancer.

yearjournalcountryeditionlanguage
2018-01-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.22132