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RESEARCH PRODUCT

Microwave assisted synthesis and solid-state characterization of lithocholyl amides of isomeric aminopyridines

Kari AhonenErkki KolehmainenMartin DračínskýManu LahtinenArto Valkonen

subject

Thermogravimetric analysisMagnetic Resonance SpectroscopyClinical BiochemistryAminopyridinesCrystal structureBiochemistryCrystalEndocrinologyIsomerismX-Ray DiffractionOrganic chemistryMicrowavesMolecular Biologyta116AminopyridinesPharmacologyChemistryOrganic ChemistryNuclear magnetic resonance spectroscopyAmidesSolid-state nuclear magnetic resonanceX-ray crystallographyThermogravimetryLithocholic AcidCrystallizationSingle crystal

description

Microwave (MW) assisted synthesis and solid state structural characterizations of novel lithocholyl amides of 2-, 3-, and 4-aminopyridine are reported. It is shown that the MW technique is a proper method in the preparation of N-lithocholyl amides of isomeric aminopyridines. It offers many advantages compared to conventional heating. The molecular and crystal structures as well as the polymorphic and hydrated forms of prepared conjugates with their thermodynamic stabilities have been characterized by means of high resolution liquid- and solid-state NMR spectroscopy, single crystal and powder X-ray diffraction, and thermogravimetric analysis. Owing to the many biological functions of bile acids and amino substituted nitrogen heterocycles, knowledge of the crystal packing of these novel conjugates may have relevance for potential pharmaceutical applications.

yearjournalcountryeditionlanguage
2011-02-01Steroids
10.1016/j.steroids.2010.11.007https://doi.org/10.1016/j.steroids.2010.11.007