6533b82afe1ef96bd128c253
RESEARCH PRODUCT
Expression of epithelial antigens EPM-1 and EXO-1 in normal, transitional, inflammatory and neoplastic colorectal mucosa
Reinhard KlingelK H Meyer Zum BüschenfeldeFrancisco X. RealWolfgang Dippoldsubject
Cancer ResearchPathologymedicine.medical_specialtyColonmedicine.drug_classCryptBiologyMonoclonal antibodyEpitopeGlycolipidCrohn DiseaseAntigenAntigens Neoplasmparasitic diseasesmedicineHumansIntestinal Mucosachemistry.chemical_classificationMembrane GlycoproteinsMucinRectumIntestinal PolypsImmunohistochemistryStainingOncologychemistryAntigens SurfaceColitis UlcerativeColorectal NeoplasmsGlycoproteindescription
EPM-1 (a high molecular weight glycoprotein) and EXO-1 (a carbohydrate epitope expressed on polar neutral glycolipids and mucins) are two developmental antigens of normal and neoplastic human epithelia and were characterised by monoclonal antibodies. Their distribution was investigated in normal and pathological human colorectal mucosa. In normal mucosa, EPM-1 and EXO-1 showed characteristic expression patterns. EPM-1 was differentially expressed along the crypt villus axis with maximum at the crypt basis. EXO-1 was present throughout the whole mucosa. The characteristic gradient of EPM-1 expression along the crypt axis in normal mucosa was no longer detectable in benign polyps. Intact gradient of EPM-1 staining discriminated between neoplastic changes of the benign adenomatous polyp and mucosal inflammation. Neoplastic mucosa in benign polyps and especially atypical glands in highly differentiated tumours showed essentially identical expression patterns. In colorectal carcinomas the overall reactivities for EPM-1 and EXO-1 were independently associated with the histopathological grade of tumour differentiation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | European Journal of Cancer |