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RESEARCH PRODUCT
Do urocortins have a role in treating cardiovascular disease?
Nikoleta KefalaFani LalidouEkaterini ChatzakiIoannis DrososStavroula Baritakisubject
0301 basic medicineendocrine systemCorticotropin-Releasing HormoneDiseaseBioinformaticsCardiovascular SystemPathogenesis03 medical and health sciences0302 clinical medicineDrug Discoveryotorhinolaryngologic diseasesMedicineAnimalsHumansUrocortinsPharmacologyUrocortinbusiness.industrymedicine.diseaseClinical trial030104 developmental biologyCardiovascular Diseases030220 oncology & carcinogenesisHeart failurebusinessIschemic heartUrocortinsdescription
Corticotropin-releasing factor (CRF) and the three homolog neuropeptides, urocortin (UCN) 1, 2 and 3, are the major neuroendocrine factors implicated in the response of the body to stress. Recent evidence suggests that UCNs have a significant role in the pathogenesis and management of cardiovascular disease, such as congestive heart failure, ischemic heart disease, and hypertension. These data led to the initiation of clinical trials testing a possible role of UCNs in the diagnosis and therapy of cardiovascular disease, with encouraging results. Here, we summarize the available literature concerning the role of UCNs in the cardiovascular system, focusing on the emerging data creating a potential for clinical applications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-06-13 | Drug discovery today |