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RESEARCH PRODUCT

Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?

Andrea RubertLeticia BaganYolanda JiménezJose V. BaganManuel Leopoldo

subject

Malemusculoskeletal diseases0301 basic medicinemedicine.medical_specialtyNecrosismedicine.medical_treatmentOdontologíaSeverity of Illness IndexNecrosis03 medical and health sciences0302 clinical medicineOsteoprotegerinInternal medicinemedicineHumansReceptorGeneral DentistryUNESCO:CIENCIAS MÉDICASAgedOral Medicine and PathologyBisphosphonate-associated osteonecrosis of the jawbiologybusiness.industryResearchRANK LigandOsteoprotegerinCase-control studyBisphosphonatemedicine.disease030104 developmental biologyEndocrinologyOtorhinolaryngologyRANKLCase-Control Studies030220 oncology & carcinogenesisDisease Progressionbiology.proteinBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgerymedicine.symptomOsteonecrosis of the jawbusinessBiomarkers

description

We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ). A case-control study in which Group 1 consisted of 41 patients with BRONJ due to bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay. The OPG/RANKL ratio was also calculated. We determined if the mean serum values differed among the different stages of BRONJ. Serum levels of RANKL were lower in Group 1 than in Group 2 (p =0.01), and serum levels of OPG were higher in patients with BRONJ than in the controls (p =0.006). The ratio of RANKL/OPG was greater in the controls than in Group 1 (p >0.01). There were no significant differences in the serum levels of RANKL and OPG among the different stages of osteonecrosis (p >0.05). Serum levels of RANKL and OPG, and the RANKL/OPG ratio were not valuable biomarkers for determining the severity of oral lesions in patients with BRONJ. Sin financiación 1.671 JCR (2017) Q2, 41/91 Dentistry, Oral Surgery and Medicine UEV

yearjournalcountryeditionlanguage
2017-08-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.22128