6533b82bfe1ef96bd128cda1

RESEARCH PRODUCT

A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue

Stéphane BinczakBinbin XuJean-marie BilbaultGabriel LaurentSabir Jacquir

subject

medicine.medical_specialtyRadiofrequency ablationGeneral Mathematics[MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS][ MATH.MATH-DS ] Mathematics [math]/Dynamical Systems [math.DS][ NLIN.NLIN-CD ] Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD]General Physics and AstronomyStimulation030204 cardiovascular system & hematology01 natural scienceslaw.invention03 medical and health sciences0302 clinical medicine[ MATH.MATH-AP ] Mathematics [math]/Analysis of PDEs [math.AP][SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemlawInternal medicine0103 physical sciencesMedicine[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP]010306 general physicsSpiralbusiness.industryApplied MathematicsSodium channelCardiac arrhythmiaStatistical and Nonlinear PhysicsAtrial fibrillation[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemmedicine.diseaseElectrical stimulationsElectrical cardioversion[NLIN.NLIN-CD]Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD]Cardiologybusiness

description

International audience; Atrial fibrillation (AF) is the most common cardiac arrhythmia whose mechanisms are thought to be mainly due to the self perpetuation of spiral waves (SW). To date, available treatment strategies (antiarrhythmic drugs, radiofrequency ablation of the substrate, electrical cardioversion) to restore and to maintain a normal sinus rhythm have limitations and are associated with AF recurrences. The aim of this study was to assess a way of suppressing SW by applying multifocal electrical stimulations in a simulated cardiac tissue using a 2D FitzHugh-Nagumo model specially convenient for AF investigations. We identified stimulation parameters for successful termination of SW. However, SW reinduction, following the electrical stimuli, leads us to develop a hybrid strategy based on sodium channel modification for the simulated tissue.

yearjournalcountryeditionlanguage
2011-08-01
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00631743