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RESEARCH PRODUCT
Influence of Substrate Hydrophilicity on Structural Properties of Supported Lipid Systems on Graphene, Graphene Oxides, and Silica
Timothée RivelTimothée RivelTimothée RivelMariia SavenkoChristophe RamseyerSemen O. YesylevskyySemen O. Yesylevskyysubject
Materials scienceSilicon dioxideLipid BilayersMolecular Conformation02 engineering and technologyModel lipid bilayer010402 general chemistry01 natural scienceslaw.inventionchemistry.chemical_compoundlawMonolayerMaterials ChemistryPhysical and Theoretical ChemistryLipid bilayerGrapheneBilayerSubstrate (chemistry)Silicon Dioxide021001 nanoscience & nanotechnology0104 chemical sciencesSurfaces Coatings and FilmschemistryChemical engineeringPhosphatidylcholinesGraphitelipids (amino acids peptides and proteins)0210 nano-technologyHydrophobic and Hydrophilic InteractionsLayer (electronics)description
Pristine graphene, a range of graphene oxides, and silica substrates were used to investigate the effect of surface hydrophilicity on supported lipid bilayers by means of all-atom molecular dynamics simulations. Supported 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid bilayers were found in close-contact conformations with hydrophilic substrates with as low as 5% oxidation level, while self-assembled monolayers occur on pure hydrophobic graphene only. Lipids and water at the surface undergo large redistribution to maintain the stability of the supported bilayers. Deposition of bicelles on increasingly hydrophilic substrates shows the continuous process of reshaping of the supported system and makes intermediate stages between self-assembled monolayers and supported bilayers. The bilayer thickness changes with hydrophilicity in a complex manner, while the number of water molecules per lipid in the hydration layer increases together with hydrophilicity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-07-21 | The Journal of Physical Chemistry B |