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RESEARCH PRODUCT

Neuroinvasion and Viral Reservoir in COVID-19.

Juan Moisés De La SernaMarcos Altable Pérez

subject

Nervous systemCentral nervous systemInfectious DiseaseDisease030204 cardiovascular system & hematologymedicine.disease_causeVirusneuroinvasionneuroinflammationPathogenesis03 medical and health sciences0302 clinical medicinemedicinePathologytrigeminalNeuroinflammationCoronavirusbusiness.industryGeneral Engineeringace2central nervous systemmedicine.anatomical_structureNicotinic agonistNeurologycovid-19Immunologybusiness030217 neurology & neurosurgerynicotine

description

The new coronavirus disease 2019 (COVID-19) has a remarkably high transmissibility potential and sometimes invades the central nervous system (CNS). The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting. Currently, there are only three main theories about it: direct neuroinvasion; blood-brain barrier (BBB) crossing and nicotinic hypothesis. Because of the rapid expansion of a virus that until now was unknown, it is necessary to know the mechanisms by which severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) generates the disease. The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting, since it is the least studied question with more innovative theories that could explain not only neurological complications, but also the primary infection and the involvement of the various organs and systems.

yearjournalcountryeditionlanguage
2020-10-18Cureus
10.7759/cureus.11014https://pubmed.ncbi.nlm.nih.gov/33214943