6533b82bfe1ef96bd128cf0d
RESEARCH PRODUCT
Treatment of hepatocellular carcinoma: present and future
Chiara GencoRomano PMassimo MidiriMassino GaliaClaudio GenovaN. AlessiSanti Maurizio RaineriGiuseppe BrancatelliCalogero CammàGiuseppe CabibboAntonello GiarratanoG. ButeraMarcello Maidasubject
OncologySorafenibmedicine.medical_specialtyCarcinoma HepatocellularOrthotopic liver transplantationHepatocellular carcinomabusiness.industryLiver NeoplasmsCancermedicine.diseaseCombined Modality TherapySystemic therapyOncologyHepatocellular carcinomaInternal medicinemedicineCarcinomaAnimalsHumansCombined Modality TherapyPharmacology (medical)In patientbusinessmedicine.drugdescription
Hepatocellular carcinoma is a major health problem. It is the sixth most common cancer worldwide and the third most common cause of cancer-related death. Despite the availability of several treatment opportunities, diagnosis is still made in an advanced phase, limiting application of most therapeutic choices that currently are based on the Barcelona Clinic Cancer Liver Classification and include surgical resection, orthotopic liver transplantation and ablative methods for very early and early disease, arterial chemoembolization for intermediate stages and systemic therapy with sorafenib for advanced hepatocellular carcinoma. Thanks to novel advancements in knowledge of molecular pathogenesis of this tumor, many new systemic agents and locoregional treatments are in different stages of clinical development and they represent an important promise of further improvements in patients' survival.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-04-01 | Expert Review of Anticancer Therapy |