6533b82bfe1ef96bd128d678

RESEARCH PRODUCT

Auditory event-related potentials at preschool age in children born very preterm.

Minna HuotilainenMinna HuotilainenMinna HuotilainenMagnus LindgrenVineta FellmanVineta FellmanHolger HövelIngmar RosénEino PartanenEino Partanen

subject

Malemedicine.medical_specialtyNeurologyAuditory eventMismatch negativityAudiologyPhysiology (medical)medicineHumansChildOddball paradigmPreschool childInfant NewbornCognitionmedicine.diseaseSensory SystemsVery pretermNeurologyAsperger syndromeChild PreschoolInfant Extremely PrematureEvoked Potentials AuditoryFemaleNeurology (clinical)PsychologyCognition Disorders

description

Abstract Objective To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4±1.9 gestational weeks, n =70) with a high risk of cognitive dysfunction. Methods We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration). Results The P1 and N2 latencies were inversely correlated to age (50–63months) both in VP ( r =−0.451, p r =−0.305, p= 0.01, respectively) and term born controls (TC; n =15). VP children had smaller P1 than near-term ( n =12) or TC (1.70±0.17μV vs 2.68±0.41 and 2.92±0.43, respectively; p Conclusions Our data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children. Significance In ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits.

yearjournalcountryeditionlanguage
2014-01-01
http://lup.lub.lu.se/record/4143845/file/4295012.pdf