Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

6533b82bfe1ef96bd128d8b7

RESEARCH PRODUCT

Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

C Khatri Ae Ward D Nepogodiev I Ahmed D Chaudhry F Dhaif B Bankhad-kendall H Kaafarani C Bretherton A Mahmood L Marais N Parsons A Bhangu A Metcalfe N Parsons C Khatri K Siaw-acheampong D Chaudhry Be Dawson Jp Evans Jc Glasbey Rr Gujjuri E Heritage Cs Jones Sk Kamarajah C Khatri Jm Keatley S Lawday E Li Sc Mckay D Nepogodiev G Pellino A Tiwari Jff Simoes Im Trout Ml Venn Rjw Wilkin A Bhangu Ao Ademuyiwa A Agarwal E Al Ameer D Alderson O Alser Ap Arnaud Km Augestad B Bankhead-kendall Ra Benson S Chakrabortee R Blanco-colino A Brar A Minaya Bravo Ka Breen I Lima Buarque E Caruana Mf Cunha Gh Davidson A Desai S Di Saverio J Edwards M Elhadi S Farik M Fiore Je Fitzgerald S Ford G Gallo D Ghosh Gma Gomes E Griffiths C Halkias Em Harrison P Hutchinson A Isik H Kaafarani A Kolias I Lawani H Lederhuber S Leventoglu Mw Loffler J Martin H Mashbari D Mazingi H Mohan R Moore D Moszkowicz Js Ng-kamstra S Metallidis S Moug M Niquen F Ntirenganya O Outani F Pata Td Pinkney P Pockney D Radenkovic A Ramos-de La Medina K Roberts I Santos A Schache A Schnitzbauer Gd Stewart R Shaw S Shu K Soreide A Spinelli S Sundar S Tabiri P Townend G Tsoulfas G Van Ramshorst R Vidya D Vimalachandran N Wright Jff Simoes Jkc Mak R Kulkarni N Sharma P Nankivell F Tirotta A Parente O Breik A Kisiel Ld Cato S Saeed A Bhangu E Griffiths Am Pathanki S Ford A Desai M Almond M Kamal A Chebaro K Lecolle S Truant M El Amrani P Zerbib Fr Pruvot D Mathieu E Surmei L Mattei H Marin J Dudek T Singhal S El-hasani D Nehra A Walters J Cuschieri Gh Davidson M Ho Rg Wade J Johnstone G Bourke A Brunelli H Elkadi M Otify C Pompili Jr Burke E Bagouri M Chowdhury Z Abual-rub A Kaufmann S Munot T Lo A Young M Kowal J Wall A Peckham-cooper Sc Winter E Belcher D Stavroulias F Di Chiara K Wallwork A Qureishi M Lami S Sravanam S Mastoridis K Shah S Chidambaram R Smillie Av Shaw S Bandyopadhyay C Cernei C Bretherton D Jeyaretna M Ganau Rj Piper E Duck S Brown C Jelley Sc Tucker G Bond-smith Xl Griffin Gd Tebala N Neal M Vatish Tm Noton H Ghattaura M Maher H Fu Obf Risk Soleymani H Majd S Sinha S Shankar A Aggarwal H Kharkar K Lakhoo C Verberne S Mastoridis A Senent-boza A Sanchez-arteaga I Benitez-linero F Manresa-manresa L Tallon-aguilar L Melero-cortes Mr Fernandez-marin Vm Duran-munoz-cruzado I Ramallo-solis P Beltran-miranda F Pareja-ciuro Bt Anton-eguia Ac Dawson A Drane F Oliva Mompean J Gomez-rosado J Reguera-rosal J Valdes-hernandez L Capitan-morales Md Del Toro Lopez M Patel A Shabana A Alanbuki O Usman A Tang Aj Beamish C Price D Bosanquet D Magowan F Solari G Williams H Nassa L Smith L Elliott G Mccabe D Holroyd Nb Jamieson Nm Mariani V Nicastro Z Li K Parkins N Spencer R Harries Rj Egan D Motter C Jenvey R Mahoney N Fine T Minto A Henry C Gill N Dunne Dr Sarma C Godbole W Carlos N Tewari D Jeevan P Naredla A Khajuria H Connolly S Robertson C Sweeney G Di Taranto S Shanbhag K Dickson K Mcevoy J Skillman M Sait H Al-omishy M Baig B Heer R Lunevicius Arg Sheel M Sundhu Aja Santini Msat Fathelbab Kma Hussein Qm Nunes Rp Jones K Shahzad I Haq Mmas Baig Jl Hughes A Kattakayam K Rajput N Misra Sb Shah Al Clynch N Georgopoulou Hm Sharples Aa Apampa Ic Nzenwa A Sud D Podolsky Nl Coleman Mp Callahan M Dunstan P Beak I Gerogiannis A Ebrahim A Alwadiya A Goyal A Phillips A Bhalla C Demetriou E Grimley E Theophilidou E Ogden Fl Malcolm G Davies-jones Jck Ng M Mirza M Hassan N Elmaleh P Daliya S Williams A Bateman Z Chia J A'court A Konarski G Faulkner R Talwar K Patel A Askari Ps Jambulingam S Shaw A Maity C Hatzantonis J Sagar S Kudchadkar N Cirocchi Ch Chan H Eberbach J Bayer B Erdle R Sandkamp H Kaafarani K Breen B Bankhead-kendall O Alser H Mashbari G Velmahos Lr Maurer M El Moheb A Gaitanidis L Naar Ma Christensen C Kapoen K Langeveld M El Hechi A Mokhtari B Main T Maccabe C Newton Ns Blencowe Dp Fudulu D Bhojwani M Baquedano M Caputo F Rapetto O Flannery A Hassan J Edwards A Ward D Tadross L Majkowski C Blundell S Forlani R Nair S Guha Sr Brown C Steele Cj Kelty T Newman M Lee G Chetty G Lye Sp Balasubramanian Sureshkumar N Shah M Sherif A Al-mukhtar E Whitehall A Giblin F Wells A Sharkey A Adamec S Madan J Konsten M Van Heinsbergen A Sou D Simpson E Hamilton J Blair J Jimeno Fraile D Morales-garcia M Carrillo-rivas E Toledo Martinez A Pascual A Landaluce-olavarria M Gonzalez De Miguel Fernandez L Gomez Cruzado E Begona D Lecumberri A Calvo Rey Gm Prada Hervella L Dos Santos Carregal Fernandez Mi Rodriguez M Freijeiro S El Drubi Vega J Van Den Eynde W Oosterlinck R Van Den Eynde A Sermon A Boeckxstaens A Cordonnier J De Coster J Jaekers C Politis M Miserez M Galipienso Eri Jd Garcia Montesino J Dellonder Frigole D Noriego Munoz V Lizzi F Vovola A Arminio A Cotoia Al Sarni M Bekheit Bs Kamera M Elhusseini P Sharma A Ahmeidat G Gradinariu W Cymes A Hannah G Mignot S Shaikh J Agilinko A Sgro Mm Rashid K Milne J Mcintyre Ma Akhtar A Turnbull A Brunt Ke Stewart Msj Wilson D Rutherford K Mcgivern E Massie S Duff F Moura Bc Brown A Khan P Asaad B Wadham Ia Aneke J Collis H Warburton M Thomas L Pearce Dm Fountain R Laurente Kv Sigamoney M Dasa K George Z Naqui M Galhoum C Lipede A Gabr A Radhakrishnan Mt Hasan R Kalenderov O Pathmanaban F Colombo R Chelva K Subba Ak Abou-foul M Khalefa F Hossain T Moores L Pickering J Shah J Anthoney O Emmerson K Bevan R Makin-taylor Cs Ong R Callan O Bloom R Vidya G Chauhan J Kaur A Burahee S Bleibleh N Pigadas D Snee S Bhasin A Crichton A Habeebullah As Bodla N Yassin M Mondragon V Dewan Mc Giuffrida A Marano S Palagi Di Maria S Grimaldi V Testa C Peluso F Borghi A Simonato A Puppo M D'agruma R Chiarpenello L Pellegrino F Maione D Cianflocca Ciarello V Pruiti G Giraudo E Gelarda E Dalmasso A Abrate A Daniele V Ciriello F Rosato A Garnero L Leotta M Chiozza G Anania A Urbani Koleva M Radica P Carcoforo M Portinari M Sibilla Je Archer A Odeh N Siddaiah R Baumber J Parry H Carmichael Cg Velopulos Fl Wright S Urban Jr Rc Mcintyre Tj Schroeppel Ea Hennessy J Dunn L Zier C Parmar S Mccluney S Shah Jm Munoz Vives A Osorio Cj Gomez Diaz Ca Guariglia C Soto Montesinos L Sanchon M Xicola Martinez N Guardia P Collera R Diaz Del Gobbo R Sanchez Jimenez R Farre Font R Flores Clotet Cem Brathwaite H Liu P Petrone H Hakmi Ah Sohail G Baltazar R Heckburn A Aujayeb D Townshend N Mclarty A Shenfine K Jackson C Johnson K Madhvani M Hampton Ap Hormis R Young V Miu K Sheridan L Macdonald S Green L Onos B Dean C Luney R Myatt Ma Williams J Mcveigh A Alqallaf A Ben-sassi I Mohamed K Mellor P Joshi Y Joshi R Crichton J Sonksen K Aldridge Gr Layton B Karki H Jeong S Pankhania S Asher A Folorunso S Mistry B Singh J Winyard J Mangwani Bhb Babu Asd Liyanage S Newman I Blake C Weerasinghe M Ballabio P Bisagni M Longhi T Armao M Madonini A Gagliano P Pizzini A Alga M Nordberg G Sandblom S Jallad J Lord C Anderson J El Kafsi K Logishetty A Saadya R Midha M Ip Subbiah H Ponniah T Stockdale T Bacarese-hamilton L Foster A James N Anjarwalla Marujo D Henriques R Hettige C Baban A Tenovici G Salerno J Hardie S Page F Anazor Sd King J Luck S Kazzaz S Hkruijff Jppm De Vries Pj Steinkamp Pkc Jonker Wy Van Der Plas W Bierman Y Janssen Abj Borgstein Ss Gisbertz Van Berge Mi Henegouwen D Enjuto M Perez Gonzalez P Diaz Pena J Gonzalez M Marqueta De Salas P Martinez Pascual L Rodriguez Gomez R Garces Garcia A Ramos Bonilla N Herrera-merino P Fernandez Bernabe Ep Cagigal Ortega I Hernandez Garcia E De Castro Rubio I Cervera F Kashora Mh Siddique A Singh C Barmpagianni A Basgaran A Basha V Okechukwu A Bartsch P Gallagher A Maqsood K Sahnan Ca Leo Se Lewis Hk Ubhi R Exley U Khan P Shah S Saxena N Zafar H Abdul-jabar F Mongelli M Bernasconi M Di Giuseppe D Christoforidis D La Regina M Arigoni I Liew A Al-sukaini S Mediratta D Saxena O Brown M Boal H Dean S Higgs S Stanger H Abdalaziz J Constable H Ishii R Preece G Dovell Gopi R Reddy A Dehal Hb Shah Gwv Cross P Seyed-safi Yw Smart A Kuc M Al-yaseen B Jayasankar D Balasubramaniam K Abdelsaid N Mundkur B Gallagher T Hine B Keeler Re Soulsby A Taylor E Davies O Ryska T Raymond S Rogers A Tong P Hawkin G Kinnaman A Meagher I Sharma E Holler J Dunning Y Viswanath K Freystaetter J Dixon Jn Hadfield A Hilley A Egglestone B Smith S Arkani J Freedman M Youssef L Sreedharan D Baskaran I Shaikh K Seebah J Reid D Watts V Kouritas D Chrastek G Maryan Df Gill F Khatun S Ranjit J Parakh V Sarodaya A Daadipour M Khalifa Kd Bosch V Bashkirova Ls Dvorkin Vk Kalidindi A Choudhry W Marx M Espino Segura-illa G Sanchez Aniceto Am Castano-leon L Jimenez-roldan J Delgado Fernandez A Perez Nunez A Lagares D Garcia Perez M Santas I Paredes O Esteban Sinovas L Moreno-gomez E Rubio V Vega A Vivas Lopez M Labalde Martinez O Garcia Villar Pm Pelaez Torres J Garcia-borda E Ferrero Herrero P Gomez C Eiriz Fernandez C Ojeda-thies Jm Pardo Garcia Wynn H Jones H Divecha C Whelton T Board C Hardie E Powell-smith M Alotaibi A Maashi A Zowgar M Alsakkaf O Izquierdo D Ventura J Castellanos A Lara D Escobar M Arrieta U Garcia De Cortazar I Villamor Garcia A Cioci G Ruiz M Allen K Rakoczy W Pavlis R Saberi A Sobti A Khaleel A Unnithan K Memon Pala Rr Bhaskar F Maqboul F Kamel A Al-samaraee R Madani L Kumar P Nisar S Agrawal H Llaquet Bayo N Duchateau C De Gheldere J Martin D Cheng H Yang A Fayad Ml Wood A Persad G Groot H Pham I Hakami C Boeker J Mall H Smith Af Haugstvedt M Jonsson P Caja Vivancos I Villalabeitia Ateca M Prieto Calvo H Marin P Martin Playa A Gainza Ej Aragon Achig A Rodriguez Fraga I Melchor Corcostegui G Mallabiabarrena Ormaechea Jj Garcia Gutierrez L Barbier Ma Pesantez Peralta M Jimenez Jimenez Ja Municio Martin J Gomez Suarez G Garcia Opere La Pascua Gomez M Onate Aguirre A Fernandez-colorado M De La Rosa-estadella A Gasulla-rodriguez M Serrano-martin A Peig-font S Junca-marti M Juarez-pomes S Garrido-ondono L Blasco-torres M Molina-corbacho Y Maldonado-sotoca A Gasset-teixidor J Blasco-moreu V Turrado-rodriguez Am Lacy Fb De Lacy X Morales A Carreras-castaner P Torner M Jornet-gibert M Balaguer-castro M Renau-cerrillo P Camacho-carrasco M Vives-barquiel B Campuzano-bitterling I Gracia R Pujol-muncunill M Estaire Gomez D Padilla-valverde S Sanchez-garcia D Sanchez-pelaez E Jimenez Higuera R Picon Rodriguez A Fernandez Camunas C Martinez-pinedo Ep Garcia Santos V Munoz-atienza A Moreno Perez Lopez Ca De La Manzanara Cano D Crego-vita M Huecas-martinez J Domenech A Rosello Anon Mj Sanguesa Jc Bernal-sprekelsen Jc Catala Bauset P Renovell Ferrer C Martinez Perez O Gil-albarova J Gilabert Estelles K Aghababyan R Rivas F Rivas J Escartin Jl Blas Laina A Nogues B Cros I Talal El-abur J Garcia Egea C Yanez Jh Kauppila E Sarjanoja S Tzedakis Pa Bouche S Gaujoux D Gossot A Seguin-givelet D Fuks M Grigoroiu Sanchez R Salas X Cathelineau P Macek Y Barbe F Rozet E Barret A Mombet N Cathala E Brian F Zadegan C Conso Aj Baldwin R West E Gammeri A Catton Marinos S Kouris J Pereca J Singh P Patel S Handa M Kaushal A Kler V Reghuram S Tezas V Oktseloglou F Mosley De La Cruz Mfi Monroy P Bobak I Omar S Ahad F Langlands V Brown M Hashem A Williams A Ridgway D Pournaras E Britton E Lostis Gk Ambler H Chu J Hopkins J Manara M Chan M Doe Rdc Moon S Lawday T Jichi W Singleton R Mannion Gd Stewart J Ramzi M Mohan Aa Singh J Ashcroft Oj Baker P Coughlin Rj Davies Azed Durst A Abood A Habeeb Ve Hudson A Kolias B Lamb L Luke S Mitrasinovic S Murphy Awt Ngu Jr O'neill S Waseem K Wong F Georgiades Pj Hutchinson Xs Tan J Pushpa-rajah A Colquhoun L Masterson I Abu-nayla C Walker A Balakrishnan S Rooney E Irune Mhv Byrne A Durrani T Richards Sethuraman A Venkatesan T Combellack J Williams G Tahhan M Mohammed M Kornaszewska V Valtzoglou I Deglurkar M Rahman U Von Oppell D Mehta M Koutentakis Syed Nong Sah Chek G Hill C Morris M Shinkwin J Torkington J Cornish R Houston S Mannan F Ayeni H Tustin M Bordenave A Robson D Vimalachandran N Manu N Eardley E Krishnan Ol Serevina E Martin C Smith A Jones Roy S Mahapatra R Clifford W Matthews K Mohankumar I Khawaja A Palepa T Doulias Y Premakumar Y Jauhari Z Koshnow D Bowen A Uberai F Hirri Bm Stubbs C Mcdonald J Manickavasagam K Ragupathy S Davison S Dalgleish N Mcgrath R Kanitkar Cj Payne L Ramsay Ce Ng T Collier K Khan R Evans C Brennan De Henshall T Drake Em Harrison V Zamvar A Tambyraja Rje Skipworth G Linder R Mcgregor P Brennan J Mayes L Ross S Smith T White Aab Jamjoom R Pasricha T Holme S Abbott A Razik S Thrumurthy J Steinke M Baker D Howden Z Baxter L Osagie M Bence Ge Fowler L Massey N Rajaretnam J Evans J John A Goubran N Campain Fd Mcdermott Js Mcgrath M Ng J Pascoe Jra Phillips Ir Daniels Da Raptis Jm Pollok N Machairas B Davidson G Fusai F Soggiu S Xyda Hidalgo C Salinas H Tzerbinis T Pissanou J Gilliland S Chowdhury M Varcada C Hart R Mirnezami J Knowles N Angamuthu V Vijay T Shakir R Hasan R Tansey E Ross M Loubani A Wilkins H Cao H Capitelli-mcmahon L Hitchman H Ikram A Andronic Aboelkassem A Ibrahim J Totty S Tayeh T Chase L Humphreys J Ayorinde A Ghanbari T Cuming K Williams E Chung R Hagger A Karim A Hainsworth M Flatman A Trompeter C Hing O Brown P Tsinaslanidis Mw Benjamin A Leyte C Tan J Smelt P Vaughan G Santhirakumaran I Hunt M Raza A Labib X Luo A Sudarsanam A Rolls O Lyons S Onida J Shalhoub K Sugand C Park Km Sarraf S Erridge J Kinross M Denning S Yalamanchili A Abuown M Ibrahim G Martin D Davenport S Wheatstone Sm Andreani Mf Bath A Sahni N Judkins Rigueros L Springford C Sohrabi J Bacarese-hamilton Fg Taylor P Patki C Tanabalan J Reynolds Me Alexander Cj Smart N Stylianides M Abdalla K Newton K Bhatia R Edmondson L Abdeh D Jones M Zeiton O Ismail H Naseem R Advani A Fell A Smith C Halkias J Evans S Nikolaou C English S Kristinsson T Oni N Ilahi K Ballantyne Z Woodward R Merh B Robertson-smith A Mahmoud P Ameerally Jg Finch C Gnanachandran I Pop M Rogers Y Yousef I Mohamed R Woods H Zahid G Mundy A Aujayeb D Townshend N Mclarty A Shenfine K Jackson C Johnson D Dass D Ford J Khan G Thiruchandran Skc Toh Y Ahmad A Allana C Bellis O Babawale Yc Phan U Lokman M Ismail T Koc A Witek L Duggleby S Shamoon S Stefan H Clancy S Singh S Mukherjee D Ferguson C Smith A Mansuri A Thakrar L Wickramarachchi R Cuthbert S Sivayoganathan K Chui E Karam C Dott S Shankar R Singh J Lane Hv Colvin A Badran A Cadersa S Williams A Cumpstey Z Hamady R Aftab F Wensley J Byrne V Morrison-jones Gk Sekhon H Shields Z Shakoor A Yener T Talbot A Khan A Alzetani R Cresner D Johnson I Hughes J Hall J Rooney S Chatterji Y Zhang R Owen M Rudic J Hunt D Zakai M Thomas A Aladeojebi M Ali A Gaunt B Barmayehvar M Kitchen M Gowda F Mansour M Jarvis E Halliday R Lefroy P Nanjaiah S Ali M Kitchen Dj Lin Ad Rajgor Rj Scurrah C Kang Lj Watson G Harris T Royle Y Cunningham G James B Steel Aco Luk G Stables A Doorgakant Vg Thiruvasagam J Carter S Reid R Mohammed W Marlow H Ferguson R Wilkin C Konstantinou D Yershov J Vatish A Denning R Das S Powell C Magee K Agarwal E Mangos T Nambirajan I Flindall V Mahendran A Hanson J De Marchi A Hill T Farrell Nf Davis D Kearney T Nelson A Picciariello V Papagni Df Altomare S Granieri C Cotsoglou A Cabeleira C Branco P Serralheiro R Alves T Teles A Lazaro C Canhoto J Simoes M Costa Ac Almeida O Nogueira A Oliveira R Athayde Nemesio M Silva C Lopes Mj Amaral A Valente Da Costa R Andrade R Martins A Guimaraes P Guerreiro A Ruivo C Camacho M Duque E Santos D Breda Jm Oliveira Al De Oliveira Lopez S Garrido M Colino J De Barros S Correia M Rodrigues P Cardoso R Martins J Teixeira Ap Soares H Morais R Pereira T Revez Mi Manso Jc Domingues P Henriques R Ribeiro Vi Ribeiro N Cardoso S Sousa S Martins Dos Santos P Miranda R Garrido M Peralta Ferreira J Ascensao B Costeira C Cunha L Rio Rodrigues M Sousa Fernandes P Azevedo J Ribeiro I Lourenco H Gomes G Mendinhos A Nobre Pinto P Cardoso R Martins J Teixeira Ap Soares H Morais R Pereira T Revez Mi Manso Jc Domingues P Henriques R Ribeiro Vi Ribeiro N Cardoso S Sousa G Martins Dos Santos H Taflin H Abdou J Diaz M Richmond J Clark L O'meara N Hanna Z Cooper A Salim Sa Hirji A Brown C Chung L Hansen Bu Okafor V Roxo Cp Raut Js Jolissaint Da Mahvi C Reinke S Ross K Thompson D Manning R Perkins A Volpe S Merola A Ssentongo P Ssentongo Js Oh J Hazelton J Maines N Gusani M Garner S Horvath Rcg Martin N Bhutiani R Choron G Peck F Soliman S Rehman A Abbas A Soliman B Kim C Jones Mde Dauer E Renza-stingone E Hernandez E Gokcen E Kropf H Sufrin H Hirsch H Ross J Engel J Sewards J Diaz J Poggio K Sanserino L Rae M Philp M Metro P Mcnelis R Petrov S Rehman T Pazionis M Quintana H Jackson Db Lumenta Sp Nischwitz E Richtig M Pau P Srekl-filzmaier N Eibinger B Michelitsch M Fediuk A Papinutti G Seidel J Kahn Tu Cohnert E Kantor J Kahiu N Hossain S Hosny A Sultana M Taggarsi L Vitone J Lambert Op Vaz I Sarantitis D Shrestha S Timbrell A Shugaba Gp Jones A Gardner Ss Tripathi Ms Greenhalgh H Emerson K Vejsbjerg L Pearce W Mccormick A Fisher K Singisetti Y Aawsaj C Barry J Blanco R Vanker M Ghobrial G Jones S Kanthasamy H Fawi M Awadallah F Chen J Cheung S Tingle F Abbadessa A Sachdeva B Rai Cd Chan I Mcpherson K Booth Mahmoud F Ali S Pandanaboyana T Grainger S Nandhra A Patience A Rogers C Roy T Williams N Dawe C Mccaffer J Riches S Bhattacharya J Moir Ns Kalson Elamin H Ahmed C Mellor C Saleh Rm Koshy J Hammond L Sanderson S Wahed Aw Phillips K Ghosh Lj Rogers Pl Labib D Miller G Minto N Hope A Marchbank K Emslie P Panahi B Ho C Perkins E Clough H Roy I Enemosah R Campbell J Natale K Gohil M Rela N Raza C Menakaya Ji Webb M Antar N Modi R Sofat J Noel R Nunn S Adegbola F Eriberto V Sharma R Tanna S Lodhia L Carvalho C Osorio J Antunes S Lourenco P Balau M Godinho A Pereira Deborah S Keller Neil J Smart Covidsurg Collaborative

subject

Male medicine.medical_specialty 2474 Multivariate analysis MORTALITY-RATES hip SURGERY Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MULTICENTER COVIDSurg Collaborative 1117 Public Health and Health Services Cohort Studies Medicine General & Internal Internal medicine General & Internal Medicine medicine Dementia Humans 1506 Prospective Studies Aged 80 and over COMPLICATIONS Science & Technology HIP-FRACTURES business.industry Hip Fractures SARS-CoV-2 R COVID-19 1103 Clinical Sciences General Medicine Femoral fracture Perioperative medicine.disease Heart failure trauma management Medicine Surgery 1737 business Life Sciences & Biomedicine Femoral Fractures Kidney disease Cohort study 1199 Other Medical and Health Sciences

description

ObjectivesStudies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644

year	journal	country	edition	language
2021-11-01	BMJ Open

10.1136/bmjopen-2021-050830 http://europepmc.org/articles/PMC8634634