6533b82bfe1ef96bd128d91b
RESEARCH PRODUCT
In vitro evaluation of leishmanicidal properties of a new family of monodimensional coordination polymers based on diclofenac ligand
Rubén Martín-escolanoJosé M. SecoJavier CepedaAmalia García-garcíaAlfonso Salinas-castilloDuane ChoquesilloAntonio Rodríguez-diéguezAna Belén Ruiz-muelleManuel Sánchez-morenoIgnacio FernándezClotilde MarínJosé Manuel MéndezSantiago Gómez-ruizsubject
chemistry.chemical_classificationDiclofenac010405 organic chemistryLigandMagnetismChainschemistry.chemical_elementTransition metalsCrystal structure010402 general chemistry01 natural sciences0104 chemical sciencesCoordination complexInorganic ChemistryCrystallographyNickelTransition metalchemistryOctahedronMaterials ChemistryMoleculePhysical and Theoretical ChemistryIsostructuralLeishmaniasisdescription
Some series of isostructural chains with general formula [M(diclof)(HO)]·(EtOH) have been obtained from reaction between diclofenac ligand (diclof) and first row transition salts (M = Mn (1),Ni (2) and Co (3)). These monodimensional coordination polymers have been characterized and their crystal structures have been solved by X-ray diffraction methods, elucidating isostructural compounds that are chains with water molecules acting as bridge between different metallic centers, while diclofenac ligands are coordinated to the octahedral coordination environment of the same. Magnetic studies of these complexes have revealed the existence of moderate ferromagnetic interactions among manganese, nickel and cobalt ions, with J values of 0.1, 0.60 and 3.3 cm, respectively. It must be highlighted that in vitro leishmanicidal activity of these new complexes has been studied against three different strains of Leishmania spp. showing a higher efficacy than the reference drug Glucantime® and demonstrating the potential of these novel materials based on coordination chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 | Polyhedron |