6533b82bfe1ef96bd128e1af

RESEARCH PRODUCT

Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor-Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope.

Stefanie KeilHorst KunzChristine ClausWolfgang Dippold

subject

TetanusChemistryToxinGeneral Chemistrymedicine.diseasemedicine.disease_causeVirologyCatalysisEpitopeGlycopeptideAntigenmedicineCytotoxic T cellMUC1Conjugate

description

Proliferation of cytotoxic T-cells, a prerequisite for the development of antitumor vaccines, was induced by 1, but not by its partial structures A and B. The conjugate 1 containing a tumor-associated Sialyl-TN -MUC-1 glycopeptide antigen A and a T-cell epitope B of tetanus toxin was synthesized by fragment condensation on a solid phase.

yearjournalcountryeditionlanguage
2000-08-09Angewandte Chemie (International ed. in English)
https://pubmed.ncbi.nlm.nih.gov/29712404