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RESEARCH PRODUCT

Hypoxic burden and angiogenic factors in patients with myocardial infarction and obstructive sleep apnea

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Introduction: The amount and severity of hypoxia have been related to risk of cardiovascular events. Aim: To determine the relationship between nocturnal hypoxic burden and pro- angiogenic factors in patients with obstructive sleep apnea (OSA) and myocardial infarction (MI). Method: A prospective, observational study in patients with a first acute MI. Eligible patients underwent a polysomnography within 30 days after MI, and a serum blood sample was drawn in order to measure a panel of angiogenic factors by Luminex technology. A hypoxic burden index (HBI) was calculated as the integral area under the desaturation curve (obtained by calculating the integral of the oxygen saturation reduction below 90% and the corresponding time) divided by total sleep time (TST). Data were expressed as mean ± SD and compared using the paired and unpaired Student’s t-tests. Results: 30 patients were recruited. Mean score at Epworth scale was 5±3. OSA was diagnosed in 67.7% of them, and for subsequent analyzes they were stratified into groups A (HBI≤1; 19 patients) and B (HBI>1; 11 patients). HBI correlated with apnea-hipopnea index (Spearman=0,515, p Conclusion: HBI is related to angiogenic factors, which may predict changes in cardiac remodeling in response to hypoxia in patients after MI.