6533b82cfe1ef96bd128fe52

RESEARCH PRODUCT

Multidentate Polysarcosine-Based Ligands for Water-Soluble Quantum Dots

Wan Ki BaeLydia BraunRudolf ZentelKristina KlinkerByeong Guk JeongByeong Guk JeongMatthias BarzAna Fokina

subject

chemistry.chemical_classificationDenticityPolymers and PlasticsPolysarcosineOrganic Chemistry02 engineering and technologyPolymer010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCycloaddition0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundchemistryPolymerizationQuantum dotPolymer chemistryMaterials ChemistryAmine gas treatingAzide0210 nano-technology

description

We describe the synthesis of heterotelechelic polysarcosine polymers and their use as multidentate ligands in the preparation of stable water-soluble quantum dots (QDs). Orthogonally functionalized polysarcosine with amine and dibenzocyclooctyl (DBCO) end groups is obtained by ring-opening polymerization of N-methylglycine N-carboxyanhydride with DBCO amine as initiator. In a first postpolymerization modification step, the future biological activity of the polymeric ligands is adjusted by modification of the amine terminus. Then, in a second postpolymerization modification step, azide functionalized di- and tridentate anchor compounds are introduced to the DBCO terminus of the polysarcosine via strain-promoted azide–alkyne cycloaddition (SPAAC). Through the separate synthesis of the anchor compounds, it is possible to ensure reproducible introduction of a well-defined number of multiple anchor groups to all polymers studied. Finally, the obtained multidentate polymeric ligands are successfully used in the...

yearjournalcountryeditionlanguage
2016-05-09Macromolecules
https://doi.org/10.1021/acs.macromol.6b00582