6533b82cfe1ef96bd129005c

RESEARCH PRODUCT

Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

Frédéric BouyerNadine MillotLionel MauriziHarender Bisht

subject

Inorganic chemistryIron oxide02 engineering and technology010402 general chemistryFerric Compounds01 natural scienceschemistry.chemical_compoundPEG ratioElectrochemistryReactive dyeGeneral Materials ScienceSulfhydryl CompoundsSpectroscopychemistry.chemical_classificationMolecular Structure[ CHIM.INOR ] Chemical Sciences/Inorganic chemistry[CHIM.MATE]Chemical Sciences/Material chemistrySurfaces and Interfaces021001 nanoscience & nanotechnologyCondensed Matter PhysicsCombinatorial chemistry0104 chemical sciencesModels ChemicalchemistryIonic strength[ CHIM.MATE ] Chemical Sciences/Material chemistryThiolNanoparticlesSurface modificationSuccimer0210 nano-technologyEthylene glycolIron oxide nanoparticles

description

International audience; The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups under ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and allowed us to graft a thiol reactive fluorescent dye: tetramethylrhodamine-5-maleimide (TMRM).

yearjournalcountryeditionlanguage
2009-07-02Langmuir
https://doi.org/10.1021/la901602w