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RESEARCH PRODUCT
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study
Silvia GarazzinoAndrea Lo VecchioLuca PierantoniFrancesca Ippolita Calò CarducciFederico MarchettiAntonella MeiniElio CastagnolaGianluca VergineDaniele DonàSamantha BosisIcilio DodiElisabetta VenturiniEnrico FeliciRoberta GiaccheroMarco DeninaLuca PierriGiangiacomo NicoliniCarlotta MontagnaniAndrzej KrzysztofiakSonia BianchiniCaterina MarabottoPier-angelo TovoGiulia PruccoliMarcello LanariAlberto VillaniGuido Castelli GattinaraThe Italian Sitip-sip Pediatric Infection Study GroupValeria CaldarelliFilippo Maria SalviniGiovanni CorselloBarba Paolo DelPaola BerleseCarlo AgostoniChiara GhizziVera QuadriSara RiscassiIvana RabboneCarmelina CalitriLuisa AbbagnatoLuciana ParolaGiuseppe BanderaliIlaria PacatiSimonetta CherubiniPaola LippiAndrea GualaRino AgostinianiSalvatore CazzatoAhmad KantarLuca BaroeroNadia RossiCristina DalmazzoLaura PanigatiPaolo ManzoniAlessandro VigoLudovica FiorePasquale ComberiatiGianna BattezzatiPaola VernaGianluca TornesePaola GianinoLuca BertaccaAngelina VaccaroGiorgio ZavariseLuigi MarchionePaola GalliaPaola Di FilippoChiara CentenariAlessandra IaconoAlessandro PlebaniMarta FerrettiSara RizziSara RossinPaola MarchisioAlessandro De FantiCostantino De GiacomoGiuliana FerranteGraziano BareraPajno RobertaStefano MartelossiAlessia RocchiRosa FrancavillaValin Paola SognoMarco PoetaPiero ValentiniRaffaele PapaAnna Maria MagistàRaffaele BadolatoCarolina SaffiotiMaria Cristina GrecoPaola CostenaroMaria Di PietroSusanna EspositoGiovanni PieriMaria Valentina SpartàValentina MaffiniLaura CursiFrancesco NunziataFederica MignoneClaudia BondoneGiacomo SteraAgostina MaroldaLorenzo FioricaCaterina SabatiniMaria Rita GenoveseCristina FerrariLuisa Gallisubject
Pediatricsmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MIS-CDisease030204 cardiovascular system & hematologyPediatrics03 medical and health sciences0302 clinical medicinechildren030225 pediatricsEpidemiologymedicinebookOriginal Researchmultisystem inflammatory syndromeMIS-C COVID-19business.industrySARS-CoV-2 infectionDisease progressionlcsh:RJ1-570COVID-19lcsh:PediatricsSettore MED/38Icu admissionCOVID-19; MIS-C; SARS-CoV-2 infection; children; multisystem inflammatory syndromeMulticenter studyPediatrics Perinatology and Child HealthPediatric Infectious Diseasebook.journalbusinessdescription
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission (p < 0.01) and linearly to length of stay (p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications (p < 0.001). Viral coinfections, underlying clinical conditions, age 5–9 years and lymphopenia were statistically related to ICU admission (p < 0.05).Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 |