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RESEARCH PRODUCT

PO-0322 The Effective Dose Of Sodium Bicarbonate In Severe Acute Dehydration And Metabolic Acidosis Due To Acute Diarrhoea In Children

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Background Still exist controversies about sodium bicarbonate (SB) effectiveness in metabolic acidosis (MA). The SB dose finally remain at discretion of physician. Aims Proving SB efficiency in severe acute dehydration (SAD) with MA secondary to acute diarrhoea (AD) in children. Methods Retrospective study conducted between May–September 2013, in 0–5 years old patients hospitalised for AD with SAD and MA. We chose the propitious age group and season for acute gastrointestinal pathology. We considered SAD loss >10% of body weight and severe MA pH Results In A Group, at admission, 57,14% presented pH 15; at 4 H, all presented alkalosis. In B Group, at admission, 50% presented severe MA; at 1 H, 25% presented alkalemia, 50% bicarbonate 86,04% presented respiratory compensation (RC), pCO 2 around 20 mmHg. Percentage of patients which developed alkalosis was significantly greater in A than B Group (p 0,004); no significance between C and B Group (p 0,57). Conclusions In choosing the bicarbonate dose in metabolic acidosis, the physician should consider also the RC, especially at 2 meq/kg dose.