6533b82dfe1ef96bd1290894
RESEARCH PRODUCT
Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2′-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity
Subrata DasJorge PasánAnandan RanjaniDharumadurai DhanasekaranSubhasish SahaLoganathan GayathriMilan MajiMohammad Abdulkader AkbarshaBhaskar Biswassubject
010405 organic chemistryStereochemistrySupramolecular chemistrychemistry.chemical_elementGeneral ChemistryCrystal structure010402 general chemistry01 natural scienceshumanities22'-Bipyridine0104 chemical scienceschemistry.chemical_compoundgenomic DNAchemistryNitrateMoleculeWater clusterCobaltdescription
A mononuclear cobalt(III) complex [Co(bpy)2Cl2]NO3⋅2H2O (1) (bpy = 2,2′-bipyridine) has been synthesized and crystallographically characterized. Self-assembly of the lattice water molecules from rectangular tetrameric water cluster interacts with nitrate anion along the c-axis forming a six membered hexagonal water-nitrate cluster. It presents a new mode of association of water molecules with nitrate molecules which is not predicted theoretically or found experimentally. The molecule effectively cleaves bacterial genomic DNA and shows important cytotoxicity against human hepatocarcinoma cell (HepG2).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-21 | Journal of Chemical Sciences |