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RESEARCH PRODUCT
Analysis of spatial diffusion of ferric ions in PVA-GTA gel dosimeters through magnetic resonance imaging
Salvatore GalloSalvatore GalloSalvatore GalloStefania NiciSanto CaracappaMaurizio MarraleMaurizio MarraleGiorgio ColluraGiorgio ColluraLuigi TranchinaB. AbbateSandra MarineoFrancesco D'erricoFrancesco D'erricosubject
Nuclear and High Energy PhysicsSettore ING-IND/20 - Misure E Strumentazione NucleariAnalytical chemistry01 natural sciences030218 nuclear medicine & medical imagingIon03 medical and health scienceschemistry.chemical_compound0302 clinical medicineNuclear magnetic resonanceMagnetic resonance imagingSpectrophotometry0103 physical sciencesmedicineAgarose gelIrradiationDiffusion (business)Image resolutionInstrumentationAgarose gel; Clinical photons beam; Gel dosimetry; Magnetic resonance imaging; PVA gel; Nuclear and High Energy Physics; InstrumentationSettore CHIM/02 - Chimica Fisicamedicine.diagnostic_test010308 nuclear & particles physicsfungiSettore FIS/01 - Fisica SperimentalePVA gelSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)chemistryDiffusion processClinical photons beamFerricAgaroseGel dosimetrySettore MED/36 - Diagnostica Per Immagini E Radioterapiamedicine.drugdescription
Abstract This work focused on the analysis of the temporal diffusion of ferric ions through PVA-GTA gel dosimeters. PVA-GTA gel samples, partly exposed with 6 MV X-rays in order to create an initial steep gradient, were mapped using magnetic resonance imaging on a 7T MRI scanner for small animals. Multiple images of the gels were acquired over several hours after irradiation and were analyzed to quantitatively extract the signal profile. The spatial resolution achieved is 200 μm and this makes this technique particularly suitable for the analysis of steep gradients of ferric ion concentration. The results obtained with PVA-GTA gels were compared with those achieved with agarose gels, which is a standard dosimetric gel formulation. The analysis showed that the diffusion process is much slower (more than five times) for PVA-GTA gels than for agarose ones. Furthermore, it is noteworthy that the diffusion coefficient value obtained through MRI analysis is significantly consistent with that obtained in separate study Marini et al. (Submitted for publication) using a totally independent method such as spectrophotometry. This is a valuable result highlighting that the good dosimetric features of this gel matrix not only can be reproduced but also can be measured through independent experimental techniques based on different physical principles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-01 |