6533b82dfe1ef96bd1291299

RESEARCH PRODUCT

Effect of nimodipine on rheologic parameters in patients with chronic cerebrovascular disease

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Abstract Sixteen patients with chronic cerebrovascular disease were treated with a monotherapeutic regimen of nimodipine 30 mg orally three times a day. At baseline and after 45 and 90 days of therapy, the patients' whole blood filterability, erythrocyte membrane fluidity, red blood cell membrane protein lateral mobility, and red blood cell Ca 2+ content (total and cytosolic) were evaluated. After 45 days, an increase in whole blood filterability and a decrease in the cytosolic red cell Ca 2+ content was seen. At the end of treatment, whole blood filterability, erythrocyte membrane fluidity, and red cell membrane protein lateral mobility had increased, compared with baseline values, while the total and cytosolic red cell Ca 2+ content had significantly decreased. These findings demonstrate that nimodipine not only influences red blood cell calcium but also acts on the macro- and microrheologic patterns.