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RESEARCH PRODUCT

Oral Squamous Cell Carcinoma Mimicking Medication-Related Osteonecrosis of the Jaws (MRONJ): A Case Series

Rodolfo MauceriCorrado ToroGiuseppina CampisiMartina Iurato CarboneVera PanzarellaVito Rodolico

subject

medicine.medical_specialtymedicine.diagnostic_testbusiness.industryOsteoporosisONJPhysical examinationRK1-715Dehiscencemedicine.diseaseMRONJDermatologyOral Squamous Cell CarcinomaMedication-Related Osteonecrosis of the Jaws MRONJ Case Seriesoral squamous cell carcinomastomatognathic diseasesosteonecrosis of the jawRadiological weaponDentistrymedicinebone exposureIn patientBasal cellOSCCOsteonecrosis of the jawbusinessAdverse drug reaction

description

(1) Background: Medication-related osteonecrosis of the jaw (MRONJ) is a potential adverse drug reaction of antiresorptive and/or antiangiogenic treatment. MRONJ is mostly diagnosed by anamnestic data, clinical examination and radiological findings, with signs and symptoms often unspecific. On the other hand, oral squamous cell carcinoma (OSCC) is characteristic for its pleomorphic appearance (e.g., ulcer, mucous dehiscence, non-healing post-extractive socket). We report three cases where OSCC mimicked MRONJ lesions. (2) Patients: Three patients undergoing amino-bisphosphonate treatment for osteoporosis presented with areas of intraorally exposed jawbone and unspecific radiological signs compatible with MRONJ. Due to the clinical suspicious of malignant lesion, incisional biopsy for histological examination was also performed. (3) Results: Histological examination of the tissue specimen revealed the presence of OSCC. All patients underwent cancer treatment. (4) Conclusions: Several signs and symptoms of OSCC may simulate, in patients with a history of anti-resorptive, MRONJ; for these reasons, it is important to perform histologic analysis when clinicians are facing a suspicious malignant lesion.

yearjournalcountryeditionlanguage
2021-11-01
10.3390/oral1040032https://hdl.handle.net/10447/573748