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RESEARCH PRODUCT
Weight loss is associated with improvements in cognitive function among overweight and obese people: A systematic review and meta-analysis
Nicola VeroneseEnzo ManzatoBrendon StubbsGiuseppe SergiSilvia FacchiniStefania MaggiTheodore D. CoscoClaudio LuchiniLuigi FontanaMarco Solmisubject
Weight lossmedicine.medical_specialtyCognitive NeurosciencePhysical activity030209 endocrinology & metabolismOverweightlaw.invention03 medical and health sciencesBehavioral NeuroscienceCognition0302 clinical medicineRandomized controlled trialMemoryWeight losslawmedicineHumansAttentionObesityExerciseNutritionAttention; Cognition; Memory; Meta-analysis; Nutrition; Obesity; Physical activity; Weight loss; Exercise; Humans; Weight Loss; Cognition; Obesity; OverweightPhysical activityCognitionOverweightCognition Memory Attention Weight loss Obesity Meta-analysis Physical activity NutritionExecutive functionsmedicine.diseaseAttention; Cognition; Memory; Meta-analysis; Nutrition; Obesity; Physical activity; Weight loss; Neuropsychology and Physiological Psychology; Cognitive Neuroscience; Behavioral NeuroscienceObesityMeta-analysisNeuropsychology and Physiological PsychologyMeta-analysisPhysical therapymedicine.symptomPsychology030217 neurology & neurosurgerydescription
Whilst obesity is associated with a higher risk of cognitive impairment, the influence of weight loss on cognitive function in obese/overweight people is equivocal. We conducted a meta-analysis of randomized controlled trials (RCTs) and longitudinal studies evaluating the influence of voluntary weight loss on cognitive function in obese/overweight individuals. Articles were acquired from a systematic search of major databases from inception till 01/2016. A random effect meta-analysis of weight loss interventions (diet, physical activity, bariatric surgery) on different cognitive domains (memory, attention, executive functions, language and motor speed) was conducted. Twenty studies (13 longitudinal studies = 551 participants; 7 RCTs = 328 treated vs. 140 controls) were included. Weight loss was associated with a significant improvement in attention and memory in both longitudinal studies and RCTs, whereas executive function and language improved in longitudinal and RCT studies, respectively. In conclusion, intentional weight loss in obese/overweight people is associated with improvements in performance across various cognitive domains. Future adequately powered RCTs are required to confirm/refute these findings. © 2016 Elsevier Ltd
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | Neuroscience & Biobehavioral Reviews |