6533b82dfe1ef96bd1291f12

RESEARCH PRODUCT

Antifungal steroid saponins from Dioscorea cayenensis.

Tomofumi MiyamotoMarie Aleth Lacaille-duboisAlain Bertrand DongmoAnne Claire Mitaine-offerMarc Sautour

subject

Antifungal AgentsMagnetic Resonance SpectroscopyStereochemistryDioscoreaceaeSaponinPharmaceutical ScienceAlpha (ethology)Microbial Sensitivity TestsPharmacognosyPlant RootsAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryHumansBeta (finance)Candida albicansCandidaPharmacologychemistry.chemical_classificationbiologyTraditional medicineDioscoreaPlant ExtractsOrganic ChemistryDiosgeninbiology.organism_classificationComplementary and alternative medicinechemistryMolecular MedicineDioscoreaSteroidsPhytotherapy

description

From the rhizomes of Dioscorea cayenensis Lam.-Holl (Dioscoreaceae), the new 26- O- beta- D-glucopyranosyl-22-methoxy-3 beta,26-dihydroxy-25( R)-furost-5-en-3- O- alpha- L-rhamnopyranosyl-(1-->4)- alpha- L-rhamnopyranosyl-(1-->4)-[ alpha- L-rhamnopyranosyl-(1-->2)]- beta- D-glucopyranoside ( 1) was isolated together with the known dioscin ( 2) and diosgenin 3- O- alpha- L-rhamnopyranosyl-(1-->4)- alpha- L-rhamnopyranosyl-(1-->4)-[ alpha- L-rhamnopyranosyl-(1-->2)]- beta- D-glucopyranoside ( 3). Their structures were established on the basis of spectral data. Compound 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 12.5, 12.5 and 25 micro g/mL, respectively) whereas 3 showed weak activity and 1 was inactive.

yearjournalcountryeditionlanguage
2004-02-07Planta medica
10.1055/s-2004-815467https://pubmed.ncbi.nlm.nih.gov/14765305