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RESEARCH PRODUCT
Mediterranean dietary pattern and depression: the PREDIMED randomized trial
Ramon EstruchRamon EstruchJosé LapetraDolores CorellaDolores CorellaJosé Alfredo MartínezJosé Alfredo MartínezRosa M. Lamuela-raventósRosa M. Lamuela-raventósXavier PintóMaría Isabel CovasJulia WärnbergJulia WärnbergJordi Salas-salvadóDora RomagueraDora RomagueraFernando ArósAlfredo GeaAlfredo GeaEnrique Gómez-graciaEnrique Gómez-graciaAlmudena Sánchez-villegasAlmudena Sánchez-villegasEmilio RosEmilio RosMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezLuis Serra-majemLluis Serra-majemsubject
MaleMediterranean diethumanosdepresiónType 2 diabetesDiet MediterraneanTriallaw.inventionRandomized controlled triallawRisk FactorsNutsDepressió psíquicamediana edadDepression (differential diagnoses)Aged 80 and overMedicine(all)ancianoPrimary preventionTraditional medicinedietaDepressionHàbits alimentarisIncidence (epidemiology)Hazard ratioDiabetesGeneral MedicineMiddle AgedLow-fatMental depressionCardiovascular DiseasesFemaleDietaaceites de plantasResearch Articlemedicine.medical_specialtyFood habitsenfermedades cardiovasculares:Ciencias de la Salud::Nutrición y dietética [Materias Investigacion]Mediterranean cookingInternal medicineStatistical significanceMediterranean dietCuina mediterràniaDiabetes Mellitusmedicinefactores de riesgoHumansPlant OilsOlive OilAgedbusiness.industrymedicine.diseaseDietnuecesDiabetes Mellitus Type 2SpainObservational studybusinessOlive oildescription
Background: A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. Methods: This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevencion con Dieta Mediterranea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. Results: We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). Conclusions: The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2. Trial registration: This trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-20 |