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RESEARCH PRODUCT
The challenge of forgetting: Neurobiological mechanisms of auditory directed forgetting
Frederic Von WegnerHelmuth SteinmetzKenneth Sung Lai YuenMarion BehrensOlga Lucía Gamboasubject
ForgettingRadiological and Ultrasound Technologymedicine.diagnostic_testWorking memoryMechanism (biology)05 social sciencesMotivated forgetting050105 experimental psychology03 medical and health sciences0302 clinical medicineNeurologyRetrieval-induced forgettingEncoding (memory)medicine0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingNeurology (clinical)AnatomyPsychologyFunctional magnetic resonance imagingNeurocognitive030217 neurology & neurosurgeryCognitive psychologydescription
Directed forgetting (DF) is considered an adaptive mechanism to cope with unwanted memories. Understanding it is crucial to develop treatments for disorders in which thought control is an issue. With an item-method DF paradigm in an auditory form, the underlying neurocognitive processes that support auditory DF were investigated. Subjects were asked to perform multi-modal encoding of word-stimuli before knowing whether to remember or forget each word. Using functional magnetic resonance imaging, we found that DF is subserved by a right frontal-parietal-cingulate network. Both qualitative and quantitative analyses of the activation of this network show converging evidence suggesting that DF is a complex process in which active inhibition, attentional switching, and working memory are needed to manipulate both unwanted and preferred items. These results indicate that DF is a complex inhibitory mechanism which requires the crucial involvement of brain areas outside prefrontal regions to operate over attentional and working memory processes. Hum Brain Mapp 39:249-263, 2018. © 2017 Wiley Periodicals, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-28 | Human Brain Mapping |