6533b82efe1ef96bd129278e
RESEARCH PRODUCT
Preparation of white beeswax microspheres loaded with valproic acid and kinetic study of drug release
M. C. RizzoLibero Italo GiannolaV. De Carosubject
PharmacologyDrugActive ingredientValproic AcidChromatographyChemistrymedia_common.quotation_subjectOrganic ChemistryPharmaceutical SciencePharmacologyDosage formMicrosphereDrug DiscoverymedicineLiberationWettingParticle sizemedia_commonmedicine.drugdescription
AbstractThe well known antiepileptic valproic acid (1) due to the long treatment of epilepsy may induce many adverse side effects on various systems. To minimize unwanted toxic effects by kinetic control of drug release, 1 was physically entrapped into white beeswax microspheres using the meltable dispersion process utilizing wetting agents. Solid, discrete, reproducible free flowing microspheres were obtained converting the liquid drug droplets into solid material. The average drug content was 17% w/w. More than 95% of the isolated microspheres were of particle size range 200-425 µm. The microspheres were analyzed to quantify the amount of incorporated drug and to characterize the in vitro release profile. The matematical approach to drug release using standard equations indicated that the first order equationis was the most appropriate one for describing the initial drug release profile; after about the 507–60% of drug was discharged numerical data fit well with the root of time equation. The drug remov...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 |