6533b82efe1ef96bd12927ef
RESEARCH PRODUCT
Preliminary assessment of the imaging capability of the YAP–(S)PET small animal scanner in neuroscience
S. HöhnemannMarkus PielUlrich SchmittJulia TillmannsDaniela StarkChristoph HiemkeA. BartoliMarc JenneweinOliver ThewsAlberto Del GuerraNicola BelcariFrank Roeschsubject
PhysicsNuclear and High Energy PhysicsScannermedicine.medical_specialtymedicine.diagnostic_testDetectorCollimatorField of viewSingle-photon emission computed tomographylaw.inventionFeature (computer vision)lawPositron emission tomographySmall animalmedicineMedical physicsInstrumentationBiomedical engineeringdescription
The new and fully engineered version of the YAP–(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4 � 4c m 2 of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axially � 4c m + transaxially. In PET mode, the volume resolution is less than 8 mm 3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP–PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-12-01 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment |