6533b82efe1ef96bd12928f6

RESEARCH PRODUCT

Age-dependent control of collagen-dependent platelet responses by thrombospondin-1 : Comparative analysis of platelets from neonates, children, adolescents, and adults

Martin GlaunerMatthias MaasAnke C. FenderStefanie C RobertBarbara ZiegerSonja ZippelUlrike Nowak-göttlJudith LahavKatrin HerkenKerstin JurkBeate E. Kehrel

subject

0301 basic medicinecollagenAgingMedizin030204 cardiovascular system & hematologyImmature PlateletThrombospondin 10302 clinical medicinePlateletBiology (General)ChildSpectroscopyCD63medicine.diagnostic_testGeneral MedicineComputer Science ApplicationsAdenosine DiphosphateChemistryplateletsAgonistAdultBlood Plateletsmedicine.medical_specialtyAdolescentmedicine.drug_classQH301-705.5Receptors Proteinase-ActivatedCatalysisExocytosisArticleFlow cytometryInorganic Chemistry03 medical and health sciencesInternal medicineThrombospondin 1Crotalid VenomsmedicineHumansLectins C-TypePlatelet activationPhysical and Theoretical Chemistrythrombospondin-1Molecular BiologyQD1-999business.industryflow cytometryOrganic ChemistryInfant NewbornFibrinogen bindingInfantPlatelet Activationreference rangesneonates030104 developmental biologyEndocrinologybusinessPeptides

description

Platelet function is developmentally regulated. Healthy neonates do not spontaneously bleed, but their platelets are hypo-reactive to several agonists. The mechanisms underlying immature platelet function in neonates are incompletely understood. This critical issue remains challenging for the establishment of age-specific reference ranges. In this study, we evaluated platelet reactivity of five pediatric age categories, ranging from healthy full-term neonates up to adolescents (11–18 years) in comparison to healthy adults (&gt

yearjournalcountryeditionlanguage
2021-05-05
10.3390/ijms22094883https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85105314822