Effect of active compression–decompression resuscitation (ACD-CPR) on survival: a combined analysis using individual patient data

6533b82efe1ef96bd1292969

RESEARCH PRODUCT

Effect of active compression–decompression resuscitation (ACD-CPR) on survival: a combined analysis using individual patient data

Niels Keiding Keith G. Lurie Ian G. Stiell Jerry P. Nolan Helmut Sitter Euthymios Sofianos Henry Benoit Patrick Plaisance D. Mauer

subject

Male Emergency Medical Services medicine.medical_specialty Resuscitation Decompression health care facilities manpower and services medicine.medical_treatment Statistics as Topic education Heart Massage Emergency Nursing Sensitivity and Specificity health services administration Odds Ratio Emergency medical services medicine Humans Prospective Studies cardiovascular diseases Cardiopulmonary resuscitation health care economics and organizations Aged Randomized Controlled Trials as Topic business.industry Advanced cardiac life support Odds ratio Middle Aged Survival Analysis Cardiopulmonary Resuscitation Confidence interval Heart Arrest Surgery Survival Rate Logistic Models Evaluation Studies as Topic Anesthesia Emergency Medicine Female Cardiology and Cardiovascular Medicine business Complication

description

Active compression decompression resuscitation (ACD-CPR) has been developed as an alternative to standard cardiopulmonary resuscitation (S-CPR). To determine the effect of ACD-CPR on survival and neurologic outcome in patients with out-of-hospital cardiac arrest, this combined analysis involved individual patient data from 2866 patients from seven separate randomized prospective prehospital studies who had received ACD-CPR or S-CPR after out-of-hospital cardiac arrest in seven international sites. Significant improvement in 1-h survival (odds ratio (OR) = 0.83; confidence interval (CI): 0.695-0.99; P0.05) was found with ACD-CPR (n = 1410) versus S-CPR (n = 1456). The odds ratio for hospital discharge after ACD-CPR was similar (OR = 0.82; CI: 0.609-1.107, P = NS), but this finding was not statistically significant. Using the chi2-test for trend, there was a significant improvement in overall survival with ACD-CPR (P0.05) versus S-CPR. This improvement was largely due to the influence of results from one study site. Neurological outcome and complication rates were comparable between groups. Further study is needed to determine which emergency medical services systems may benefit from out-of-hospital use of ACD-CPR.

year	journal	country	edition	language
1999-10-03	Resuscitation

https://doi.org/10.1016/s0300-9572(99)00073-8