6533b82efe1ef96bd1292995
RESEARCH PRODUCT
Ischemia and post-ischemic regeneration of the small intestinal mucosa
P. HöhnR. WagnerHelmut E. Gabbertsubject
MalePathologymedicine.medical_specialtyTime FactorsIschemiadigestive systemIntestinal mucosaIschemiaIntestine SmallmedicineAnimalsRegenerationBleb (cell biology)Intestinal MucosaChemistryRegeneration (biology)digestive oral and skin physiologyHistologyGeneral Medicinemedicine.diseaseEpitheliumRatsSmall intestinal mucosamedicine.anatomical_structureAutoradiographyLigationdescription
After reversible ligation of the arcade vessels of the proximal jejunum, the intestinal mucosa was investigated by light microscopic and autoradiographic methods after 15, 30, 60, 120 and 300 min of ischemia. Early ischemic damage to the mucosa (after about 15 min) is characterized by shedding of not yet irreversibly damaged enterocytes from the tips of the villi into the intestinal lumen and bleb formation starting at the base of the epithelia. This process advances from the tips to the bases of the villi with increasing duration of ischemia, and the villi are completely denuded of epithelium after ischemia lasting 2 h. Remains of the small intestinal crypts are still present at this time. After ischemia lasting for 5 h, almost the entire intestinal wall is necrotic.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-12-01 | Virchows Archiv B Cell Pathology Including Molecular Pathology |