6533b82efe1ef96bd12929ab

RESEARCH PRODUCT

Survival and prognostic factors in patients with oral squamous cell carcinoma

Melo McSarmento DjCaldas AdGustavo Pina GodoyFerreira AkCarvalho ShAbreu MhGranville-garcia AfAgripino Gg

subject

AdultOncologymedicine.medical_specialtyPoor prognosisYounger ageMultivariate analysisneoplasmsglandular and epithelial03 medical and health scienceshead and neck neoplasms0302 clinical medicineOral Cancer and Potentially malignant disordersInternal medicinefollow up studiesCox proportional hazards regressionHumansMedicineBasal cellIn patientStage (cooking)General DentistryUNESCO:CIENCIAS MÉDICASSurvival analysisRetrospective StudiesSquamous Cell Carcinoma of Head and Neckbusiness.industryResearchrare diseases030206 dentistryPrognosisstomatognathic diseasesOtorhinolaryngologyCarcinoma Squamous CellMouth NeoplasmsepidemiologySurgerybusinessBrazil

description

Background This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Material and Methods Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients’ prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. Results The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). Conclusions OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. Key words:Head and neck cancer, oral cancer, oral squamous cell carcinoma, survival, prognosis.

yearjournalcountryeditionlanguage
2020-10-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.24242